New research reveals that individuals who come off blockbuster weight-loss injections like semaglutide or tirzepatide can put back on shed pounds far faster than those who stop conventional diet and exercise regimens.
Findings released in a leading health publication shows that while obese people often shed substantial amounts of their body weight while using the jabs, the mass comes back at an average rate of 0.8 kg per month once they quit.
"People purchasing these medications must be informed of the danger of quick weight regain when the treatment ends," cautioned researcher Dr. Susan Jebb.
That rate of regain suggests a return to pre-treatment mass in about a year and a half.
Comparing Treatments
The analysis, which looked at dozens of trials involving over 9,000 of patients, compared the outcomes of the injectable medications with conventional dieting.
Researchers point out that individuals who shed pounds through lifestyle changes alone usually experience a slower creep back—around 100 grams monthly—once they finish.
Understanding the Quick Rebound
Nutrition scientists believe the way of the jabs is key to understanding the heightened weight return.
These medications copy a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Artificially providing the hormone concentrations several times higher than the body's typical production may cause the system to produce less of its own natural GLP-1, and could diminish sensitivity to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this GLP-1 'fix' means appetite is no longer kept in check, making binge eating far more likely."
A Chronic Condition?
The NHS advise the jabs for individuals with weight-linked medical conditions, alongside prescribed lifestyle changes.
Many experts say that, due to the likelihood of relapse, the treatment should be considered ongoing.
This perspective is echoed by drug manufacturers, who say that the findings "emphasize the persistent nature of obesity," similar to managing conditions like high blood pressure.
Patient Experiences
Individuals who have stopped the jabs report a sudden return of hunger.
"I experienced a trigger activating and I was suddenly starving," recalled an individual.
The struggle is exacerbated if patients have not developed lasting lifestyle or habit modifications during treatment.
Widespread Use
Recent estimates show that millions of people in the UK have used weight-loss jabs in the past year, with interest being substantial.
- Use is greater among women compared to males.
- The middle-aged demographic shows the greatest level of interest.
- Many access the drugs through private prescriptions rather than the NHS.
Ultimately, experts emphasize that while the jabs are effective tools for shedding pounds, they are not a standalone fix and lasting health benefits likely depends on combined lifestyle management.
